#Umbra vs penumbra registration

When there is a total eclipse of the Sun, the umbra is on the Earth. Siddiqui MM, Rais-Bahrami S, Turkbey B, George AK, Rothwax J, Shakir N et al (2015) Comparison of MR/ultrasound fusion-guided biopsy with ultrasound-guided biopsy for the diagnosis of prostate cancer. Notice that the Earth gets both the umbra and penumbra.

#Umbra vs penumbra registration

Cancer 122(6):884–892Įlkhoury FF, Felker ER, Kwan L et al (2019) Comparison of targeted vs systematic prostate biopsy in men who are biopsy naive: the prospective assessment of image registration in the diagnosis of prostate cancer (PAIREDCAP) Study. N Engl J Med 382(10):917–928įilson CP, Natarajan S, Margolis DJ et al (2016) Prostate cancer detection with magnetic resonance-ultrasound fusion biopsy: the role of systematic and targeted biopsies. Like the other Pokemon hacks, Rutile Ruby & Star Sapphire and Nova Sun & Umbra Moon, their main purpose is to provide a more challenging game experience while not artificially limiting the player. Lancet Oncol 20(1):100–109Īhdoot M, Wilbur AR, Reese SE et al (2020) MRI-targeted, systematic, and combined biopsy for prostate cancer diagnosis. Pokémon Supernova Sun & Penumbra Moon is a ROM hack for Pokémon Ultra Sun and Pokémon Ultra Moon on Nintendo 3DS. Rouvière O, Puech P, Renard-penna R et al (2019) Use of prostate systematic and targeted biopsy on the basis of multiparametric MRI in biopsy-naive patients (MRI-FIRST): a prospective, multicentre, paired diagnostic study. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Perilesional biopsy Prostate biopsy Prostate cancer Prostatectomy Targeted biopsy. Of the 104 patients who underwent prostatectomy, GG upgrading rate for TB+OL+PL was lower compared to TB (21 vs 36%, p < 0.001) and was not significantly different compared to TB+OL+PL+DC (21 vs 19%, p = 0.500).Ī biopsy strategy incorporating both intensive sampling of the umbra and penumbra improved csPCa detection and reduced risk of GG upgrading at prostatectomy. TB+OL+PL had greater csPCa detection compared to just TB+OL (41 vs 39%, p = 0.016) and TB+PL (41 vs 37%, p < 0.001). OL and PL cores improved the csPCa detection rate of TB from 34 to 39% (p < 0.001) and 37% (p = 0.001) respectively. OL cores detected more csPCa than PL cores (31 vs 16%, p < 0.001). Out of the 398 patients included, the median number of OL and PL cores was 5 (IQR 4-7) and 5 (IQR 3-6) respectively. The incremental csPCa detection rate (GG ≥ 2) and the rate of GG upgrading on prostatectomy as OL, PL and DC sequentially added to TB were determined. All other cores were designated as distant cores (DC). Perilesional (PL) cores were defined as adjacent cores within 10 mm of the target lesion ('penumbra') whilst overlap (OL) cores were defined as cores within the ROI itself ('umbra').

Our objective is to evaluate the clinically significant prostate cancer detection rate of overlapping and perilesional systematic biopsy cores and its impact on grade group (GG) concordance at prostatectomy.īiopsy maps of those undergoing MRI-targeted (TB) and systematic biopsy (SB) were reviewed to reclassify systematic cores.